The weightgain caused by many psychotropic drugs is a major cause for poor compliance with such medications and could also increase cardiovascular morbidity among psychiatric patients. Similarly, the weightloss mechanism of the combination is not known but is attributed to a reduction in appetite. There is a lot of difference in diet, genetics, habits, exercise, and. The truth is this drug is not for weight loss, but an individual may experience weight loss as a. It has also been used to treat alcoholism, eating disorders, tremors, obesity, diabetes and psychiatric disorders such as bipolar disorder. If a patient has not lost at least 3% of baseline body weight on qsymia 7. Topiramate has high bioavailability and low binding to serum proteins 172. Pharmacotherapy for overweight and obesity should be used only as an adjunct to. A 6month randomized, placebocontrolled, doseranging. In clinical studies, phenterminetopiramate reduced body weight by 8.
We report a case illustrating the potential anticraving effects of topiramate against chocolate, leading to. Although not fda approved for the treatment of obesity, studies in obese adults have demonstrated weight reduction of approximately 5% with 612 months of therapy. Addon topiramate reduces weight in overweight patients with. Is immediaterelease topiramate an effective treatment for. The use of topiramate at the same time as birth control medications may make the birth control product less effective. We examined predictors of weight loss with topiramate. The effect of topiramate on weight loss in patients with. You can start with a low dose of 25 or 50 mg per day, twice a day with or without food. Remember that not everyone who takes topamax will lose their weight but most people observe a significant reduction in their weight throughout their treatment. Topiramate is an effective antiepileptic medication. Topiramate topamax for migraine prevention american.
Topiramate, sold under the brand name topamax among others, is a medication used to treat epilepsy and prevent migraines. The efficacy of topiramate as an adjunct treatment in. For those with bingeeating disorder, the apa finds topiramate effective for binge reduction and weight loss, but the side effects might limit its usefulness for many people. Unlike topamax, qsymia is labeled to be used for weight loss.
Ive used topamax several times in the past, and my husband uses it now. For epilepsy this includes treatment for generalized or focal seizures. Recent reports have shown that the anticonvulsant topiramate causes weight loss in various patient groups. The mean weight loss for topiramate treated subjects who completed the study was 5. Phenterminetopiramate an overview sciencedirect topics. Finally, the drug may cause carbonated beverages to taste flat.
Newer weight loss agents are typically better tolerated, have better safety profiles, and are approved for chronic weight management including weight maintenance. Approximately 14% of the 77 pediatric patients in the 400 mgday group who received. How to use topiramate for weight loss diy remedies. The nnts to achieve weight loss of 5% or more of bbw and 10% or more of bbw were 3 95% ci, 23 and 4 95% ci, 34, respectively. The effect of topiramate on weight loss in patients with type 2 diabetes. Common side effects include tingling, loss of appetite, feeling tired, abdominal pain, hair loss, and trouble concentrating. It helps to lose weight, as it supresses the appetite. Prior to weight loss, patient was on 50 units of glargine twice daily, which was titrated off with improvement in hemoglobin a1c 15. To evaluate the efficacy and safety of topiramate tpm for weight loss in healthy obese subjects. Weight loss of 172 lb with topiramate in a patient with. Topamax adverse reactions in adult and pediatric patients were. Topiramate in bipolar and schizoaffective disorders.
Topiramate is available in tablet and capsule form 25 mg, 50 mg, 100 mg, and 200 mg. Topiramate has gained additional approvals for treatment of migraine headaches and, in combination with phentermine, for weight loss. Levels and effects may bepby phenytoin, carbamazepine,orvalproic acid. All studies showed significantly greater weight loss in the topiramate groups, regardless of dose and duration, although there was some heterogeneity among the results. This contains topiramate, which is the same active ingredient as in topamax. Usual dosing instructions for topiramate are as follows. Topiramate is an antiepileptic that is also indicated for the treatment of chronic migraines. Predictors of weight loss in adults with topiramate. The drug topiramate can help people lose weight as long as they can tolerate the side.
Evaluate weight loss after 12 weeks of treatment with qsymia 7. Medications for chronic headaches and migraines have included. Neither one of us has had luck losing weight with it. Interestingly, this weight loss was correlated with an increase in triglyceride levels 116 to 231 mgdl and improvement in hdl 27 to 39 mgdl. Alcoholuse within 6 hr before or afteruse ofextendedreleaseproduct may signi. Weight loss is most likely in the first 3 months of treatment 82%. The combination therapy achieves weight loss of a magnitude that meets the expectations of the us fda along with improvement of some obesityrelated risks. Anticraving effects of topiramate in a diabetic patient. I was in a weight loss study a couple of years ago for qsymia but had to drop out due to the harsh side effects and high blood pressure.
These eye problems can lead to permanent loss of v ision if not treated. Topiramate was first approved in the united states in 1996 for treatment of epilepsy 56. Key points older obesity pharmacotherapies are limited by tolerability and dependence issues and are approved only for shortterm use. I heard that people that completed the study lost a ton of weight. Both weight loss and weight gain were reported in that study. Topiramate use has been associated with a range of adverse events in clinical trials almost 25% of patients using topiramate for migraine prevention withdrew because of adverse events, compared with 11% of patients using placebo p phentermine topiramate phentpm, as compared with placebo, led to a. Topiramate in adolescents with severe obesity full text. Weight loss was primarily caused by reduction in body fat mass. Weight loss was noted as an adverse effect to topiramate when used to treat epilepsy.
However, weight gain is also a side effect of topamax. Weight loss in patients taking topamax appears to be dosedependent that is, higher doses of. Addon topiramate reduces weight in overweight patients. Please discuss this with your healthcare provider if you take topiramate and want to take birth control medications. There is a new weight loss drug just approved on the market called qsymia.
Topiramate not uncommonly causes weight loss, and the degree of weight reduction tends to correlate with dose and duration of therapy. It holds promise in the care of diabetic patients by virtue of its effect on weight loss 1. My weight problems are not from over eating, so i never thought that it would help me with the fluid, but my hubby has about 20 extra pounds on him from a car accident, and although it helps his migraines tremendously, he hasnt. Calabrese et al, 31 treated 10 patients hospitalised with mania with topiramate. Several studies have demonstrated the efficacy of topiramate in the treatment of bipolar disorder, including refractory populations, and in the treatment of posttraumatic stress disorder. Between 6% 16% of patients exposed to topiramate will report weight loss. Regardless of how this drug works, it is a well known offlabel pill used to lose weight. Topiramate may have benefit as a weightloss drug date.
It can be an effective tool that together, with diet and exercise, can be used for weight loss. Nda 020505s050 topamax topiramate oral tablets 25mg, 50mg, 100mg and 200mg nda 020844s041 topamax topiramate sprinkle capsules 15mg, and 25mg fda approved labeling text dated september 2012 page 4 of 71. Topiramate, a medication approved by the food and drug administration fda for the treatment of seizures in adults and children, is associated with weight loss. It is also reported efficacious as an adjunct in the treatment of alcohol dependence 2 and in the management of bingeeating disorder 3. Topiramate or topamax is an anticonvulsant medicine. Your doctor may give you a combination of phentermine and topamax. Topiramate weight loss in migraine patients topiramate weight loss in migraine patients sylvesterstallonefooddiet. Nhlbi recommends that weight loss medications should only be used in conjunction with physical activity, diet, and behavioral therapy. Topiramate in the treatment of binge eating disorder associated. Topiramate induced weight loss and improved glycemic control in obese, diabetic patients. Phenterminetopiramate qsymia national drug monograph. How to take topamax for weight loss with pictures wikihow. Your doctor may prescribe you a pill called qsymia instead.
Topiramate has been suggested as a singleagent shortterm adjuvant to exercise and caloric restriction regimens for weight loss in the nonheadache population bays, 2010. A 6month randomized, placebocontrolled, doseranging trial of topiramate for weight loss in obesity. Recently, combination of topiramate with phentermine has been evaluated in two big studies for weight loss which demonstrated near 10% weight loss and 0. In clinical trials topiramate was associated with a mean weight loss of 3. You can take topamax either with or without food, both in tablet or capsule form, however it can have a bitter taste with it. Follow your doctors instructions to take both of these pills together. Drug therapy is considered second line ahead of weight loss surgery and should be considered if a patient has not lost 1 pound per week after 6 months 4of lifestyle therapy. The drug has also shown effectiveness in open trials as a mood stabilizer in patients with.